IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Phone: (612) 626-5876
University of Texas Medical Branch, Galveston, 1997, Ph.D.
Molecular mechanisms of human cytomegalovirus replication and pathogenesis
Our laboratory is focused on understanding the molecular mechanisms of human cytomegalovirus (HCMV) replication and pathogenesis. HCMV is a ubiquitous herpesvirus that infects greater than 80% of the population. Like all herpesviruses, HCMV is capable of entering a state of latency, which provides for life-long infection following primary exposure. Clinically, HCMV is a serious pathogen that causes severe manifestations in individuals with immature or compromised immune systems. The increasing use of therapeutic immunosuppression, organ transplantation and the incidence of AIDS have all focused attention upon understanding the HCMV life cycle, with a view toward identifying approaches to attenuate primary and/or reactivated HCMV infection. Our research focuses on three areas of HCMV biology that include: 1) the generation and characterization of HCMV mutants 2) genomic approaches to study HCMV gene regulation, and 3) the virus/host cell interaction.
One of the main interests in the laboratory involves determining what role HCMV tegument molecules play during replication. These tegument molecules are packaged within the virus particle and delivered immediately upon infection to the host cell. These tegument molecules are important regulators of viral and cellular gene expression, modulators of the host anti-viral response, and are critical for “kick starting” the viral infection. Our laboratory uses numerous biochemical and genetic approaches to decipher the functions of these HCMV tegument molecules and examine what role they play in viral replication and pathogenesis.
'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.
The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.