IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Phone: (612) 624-5172
B.S. Chemistry, St. Cloud State University
M.S. Biological Chemistry, University of Michigan
Ph.D. Biological Chemistry, University of Michigan
Postdoctoral Fellow, Univesity of Minnesota
HIV lethal mutagenesis; HIV quasispecies
The high mutation rate of HIV allows for the development of drug resistance and the ability of the virus to escape immune detection. However, many mutations produced during the error-prone replication are detrimental to the virus and lead to the production of non-infectious virus. The error rate of HIV-1 is high enough to ensure enough diversity for the virus to replicate under adverse conditions such as the presence of antiviral compounds or immune surveillance, yet low enough that the virus does not accumulate enough mutations to render the virus non-infectious. It has been predicted that increasing the mutation rate above a certain threshold, known as the error threshold, would extinguish viral infectivity. As a result, drugs that increase the mutation frequency of HIV-1 past the error threshold may be a viable antiretroviral therapy. To test this, I am investigating the effects of two FDA-approved drugs (decitabine and gemcitabine) on their ability to eliminate HIV infectivity by elevating the HIV mutation rate. These studies represent a collaboration with Louis Mansky and Steven Patterson. Presently, I am extending my studies into mouse model and working on methods to deliver these drugs in a pill form. I am interested in the clinical translation of this novel combination therapy.
My graduate work at the University of Michigan focused on post-translational processing and trafficking of the Luteinizing Hormone Receptor, a GPCR critical for reproduction. While in Michigan, both course and volunteer work sparked my interest in virology with a specific focus on HIV.
In my free time, I enjoy outdoor activities and am an avid reader.
'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.
The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.