IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
There are two major projects in the laboratory. The first involves the identification of genes involved in development of human leukemia. This project is a collaborative effort between my laboratory and that of Dr. Betsy Hirsh. Dr Hirsch?s laboratory has identified a new recurrent chromosomal abnormality in young children with acute myeloid leukemia. We are cloning genes that localize to the sites of chromosomal rearrangements in tumors from these patients; one candidate gene we identified recently is novel and exhibits characteristics of a tumor suppressor gene. Studies are underway to define the function in both normal and leukemic cells of this and additional genes being cloned.
The second project takes a different approach to identify genes important in tumorigenesis and uses a retrovirus model. Many retroviruses induce leukemias; analysis of tumor DNA demonstrates that viral DNA (called a provirus) is found inserted at common sites and that these sites frequently define either oncogenes or tumor suppressor genes. We are analyzing both myeloid and B cell tumors induced by different strains of retroviruses to identify genes that are aberrantly regulated after proviral insertion. As an extension of these tumorigenesis studies, we are also investigating the role of several viral genes required for efficient replication.
'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.
The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.