Contact IMV

IMV Executive Assistant

email: virology@umn.edu

tel. (612) 624-1926

fax. (612) 625-1108

 

18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

General Questions:

virology@umn.edu

Kathleen Conklin,
Associate Professor

Genetics, Cell Biology, and Development

Email: conkl001@umn.edu
Phone: 612-626-0445

Research Interests

There are two major projects in the laboratory. The first involves the identification of genes involved in development of human leukemia. This project is a collaborative effort between my laboratory and that of Dr. Betsy Hirsh. Dr Hirsch?s laboratory has identified a new recurrent chromosomal abnormality in young children with acute myeloid leukemia. We are cloning genes that localize to the sites of chromosomal rearrangements in tumors from these patients; one candidate gene we identified recently is novel and exhibits characteristics of a tumor suppressor gene. Studies are underway to define the function in both normal and leukemic cells of this and additional genes being cloned.

The second project takes a different approach to identify genes important in tumorigenesis and uses a retrovirus model. Many retroviruses induce leukemias; analysis of tumor DNA demonstrates that viral DNA (called a provirus) is found inserted at common sites and that these sites frequently define either oncogenes or tumor suppressor genes. We are analyzing both myeloid and B cell tumors induced by different strains of retroviruses to identify genes that are aberrantly regulated after proviral insertion. As an extension of these tumorigenesis studies, we are also investigating the role of several viral genes required for efficient replication.

Selected Recent Publications

  • Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF. (2005) Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Gene.28;347(1):137-45.
  • Simmons, HM, L Oseth, P Nguyen, KF Conklin and B Hirsch. 2002. Cytogenetic and molecular heterogeneity of 7q36/12p13 rearrangements in childhood AML. Leukemia 16, 2408-2416.
  • Benson, S.J., B.L. Ruis, A.M. Fadly and K. F. Conklin. 1998. The unique envelope gene of the subgroup J avian leukosis virus derives from ev/J proviruses, a novel family of avian endogenous viruses. J. Virol. 72:10157-10164.
  • Benson, S.J., B.L. Ruis, A.L. Garbers, A.M. Fadly and K.F. Conklin. 1998. Independent isolates of the emerging subgroup J avian leukosis virus derive from a common ancestor. J. Virol. 72: 10301-10304.
  • Ruis, B.L., S.J. Benson, and K.F Conklin. 1999. Genome structure and expression of the ev/J family of avian endogenous viruses. J. Virol. 73:5345-5355.

 

 

Featured News & Events

'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.

The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.

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