Contact IMV

IMV Executive Assistant

email: virology@umn.edu

tel. (612) 624-1926

fax. (612) 625-1108

 

18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

General Questions:

virology@umn.edu

Ashley Haase,
Regents' Professor and Head

Microbiology, Medical School

Email: haase001@umn.edu

Education

MD, Columbia College of Physicians and Surgeons, 1965

Research Interests: Viral pathogenesis, HIV

My laboratory investigates the pathogenesis, treatment and prevention of lentiviral immunodeficiency infections caused by HIV-1 and its simian relative, SIV, using such technologies as in situ hybridization, in situ tetramer staining and quantitative image analysis to visualize infection and the hosts? cellular immune response in tissues. Much of our recent work has focused on sexual mucosal transmission and the acute stage of SIV infection, the roles of ?resting? and activated CD4 T cells in establishing infection, and the mechanisms of the massive depletion of CD4 T cells in the gut. Going forward, these studies provide a foundation for studies of the correlates of protection for attenuated vaccines, and the development of vaccines and microbicides to prevent transmission. My laboratory has also undertaken a comprehensive microarray analysis of HIV-1 and SIV infections with the objectives of understanding pathogenesis and identifying novel targets for treatment and prevention. Current efforts focus on broadening the microarray analysis to encompass the early through late stages of HIV-1 infection, and mapping genes identified in the analysis to gain insight into their function in HIV-1 infected lymphatic tissues, the principal sites of virus production, persistence and pathology.

Selected Recent Publications

  • Schacker T.W., Brenchley J.M., Beilman G.J., Reilly C., Pambuccian S.E., Taylor J., Skarda D., Larson M., Douek D.C, Haase A.T. 2006. Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection. Clin Vaccine Immunol. 13(5):556-60.
  • Estes J.D., Li Q., Reynolds M.R., Wietgrefe S., Duan L., Schacker T., Picker L.J., Watkins D.I., Lifson J.D., Reilly C., Carlis J., Haase A.T. 2006. Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J Infect Dis. 193(5):703-12.
  • Schacker TW, Reilly C, Beilman GJ, Taylor J, Skarda D, Krason D, Larson M, Haase AT. 2005. Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS. 19(18):2169-71.
  • Haase, A.T. 2005. Perils at mucosal front lines for HIV and SIV and and their hosts. Nature Rev. Immunol. 5: 783-792.
  • Li, Q., L. Duan, J.D. Estes, Z.-M. Ma, T. Rourke, Y. Wang, C. Reilly, J. Carlis, C.J. Miller, and A.T. Haase. 2005. Peak SIV replication in resting memory CD4 T cells depletes gut lamina propria CD4 T cells. Nature 434: 1148-1152.
  • Li, Q., T. Schacker, J. Carlis, G. Beilman, P. Nguyen, and A.T. Haase. 2004. Functional genomic analysis of the response of HIV-1 infected lymphatic tissue to antiretroviral therapy. J. Infect. Dis. 189: 572-582.
  • Zhang, Z.-Q., T. Schuler, M. Zupancic, S. Wietgrefe, K.A. Staskus, K.A. Reimann, T.A. Reinhart, M. Rogan, W. Cavert, C.J. Miller, R.S. Veazey, D. Notermans, S. Little, S.A. Danner, D.D. Richman, D. Havlir, J. Wong, H.L. Jordan, T.W. Schacker, P. Racz, K. Tenner-Racz, N.L. Letvin, S. Wolinsky, and A.T. Haase. 1999. Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286:1353-1357.
  • Haase, A.T. 1999. Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues. Annu. Rev. Immunol. 17:625-656.

 

 

Featured News & Events

'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.

The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.

About the IMV icon

Read about bacteriophage phi 29 and why it matters.

IMV Timeline

Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.

TWiV

"This Week in Virology" from professor Vincent Racaniello.