Contact IMV

IMV Executive Assistant


tel. (612) 624-1926

fax. (612) 625-1108


18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

General Questions:

Sabita Roy,
Professor, Surgery, Medical School;

Director, Division of Infection, Inflammation and Vascular Biology

Phone: (612) 624-4615



1977, B.Sc. - Biology
Panjab University, Chandigarh, India

1981, M.Sc.
All India Institute of Human Physiology
Medical Sciences, New Delhi, India

1986, Ph.D. - Neurobiology
University of Kansas, Lawrence, Kansas

Research Interests

Chronic morphine and immunosupression
- Molecular and cellular mechanism
- Consequence on wound healing events
- Susceptibility to opportunistic infection

Morphine modulation of Hypoxia induced Hif-1 alpha and consequence in angiogenesis, wound repair and intimal hyperplasia

Selected Recent Publications

  • Kelschenbach J, Barke RA, Roy S (2008) Role of Mu opioid receptor and Corticosterone in Morphine withdrawal mediated Th2 differentiation and suppression of IL-12. JNeuroimmunol. (submitted)
  • Kelschenbach J, Ninkovic J, Wang JH, Krishnan A, Charboneau R, Barke RA, Roy S (2008) Morphine withdrawal inhibits inhibits macrophage IL-12 synthesis by modulating the cAMP signaling pathway. J Immunol. (in press)
  • Wang JH, Barke RA, Charboneau R and Roy S (2008) Morphine modulation of alveolar macrophages increases pulmonary s. pneumoniae infection. J Immunology (in press).
  • Kelschenbach J, Barke RA, Roy S (2008) Role of Innate Immunity in Morphine withdrawal. J Immunol. (under revision)
  • Wang JH, Loh HH and Roy S (2008) Differential effects of-endorphin on Mu- and Delta opioid receptor. J. Neuroscience (submitted).
  • Koodie L, Ramakrishnan S and Roy S (2008) Morphine modulates tumor angiogenesis through a HIF alpha dependent pathway. Cancer Res. (submitted).
  • Wang J, Barke RA, Roy S. (2007) Transcriptional and epigenetic regulation of IL-2 gene in activated T cells by morphine. J Biol Chem. 2007 Jan 16; [Epub ahead of print]
  • Hamilton KL, Franklin LM, Roy S, Schrott LM. (2007). Prenatal opiate exposure attenuates LPS-induced fever in adult rats: Role of interleukin-1beta. Brain Res. 2007 Feb 16;1133(1):92-9.
  • Vatassery GT. Quach HT, Smith WE., SantaCruz KS and Roy S (2008) Apolipoprotein E deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochimica et Biophysica Acta Molecular Basis of Disease Jul;1772(7):797-803. Epub 2007 May 3.



Featured News & Events

'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.

The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.

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Read about bacteriophage phi 29 and why it matters.

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Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.


"This Week in Virology" from professor Vincent Racaniello.