IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Ph.D., University of Minnesota
Dr. Skinner's laboratory focuses on two distinct research projects. The goal of the first project is to gain insights into prion and Alzheimer disease pathogenesis. The goal of the second project is to gain insights into human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) pathogenesis. Prion and Alzheimer diseases are fatal neurodegenerative diseases with no known cure. Increased understanding of the molecular events that lead to neurodegeneration in each of these diseases is needed for early diagnosis and the development of new drug therapies. Current efforts in Dr. Skinner's lab involve the use of cDNA microarrays to identify alterations in gene expression that occur during prion-induced pathogenesis and Alzheimer's disease pathogenesis. The ultimate goal of the prion/Alzheimer research project is to increase our understanding of the molecular events that occur during these disease processes, identify markers for early diagnosis, and identify new targets for drug therapy. The HIV/SIV project is motivated by the fact that over 40 million people worldwide are infected with HIV. A pressing biomedical priority is the development of an effective HIV vaccine. Several lines of evidence have indicated that the development of an effective HIV vaccine will require the induction of a strong virus specific cytotoxic T lymphocyte (CTL) response. Using MHC-class I tetramers, Dr. Skinner developed a method to stain antigen specific CTLs in tissue sections. This technique is referred to as in situ tetramer staining (IST). Dr. Skinner's lab is using IST to evaluate SIV and HIV specific T cells in tissues after infection, and plans to use IST to evaluate the effects of vaccination on the development of anti-viral T cells in tissues.
'Wisc-e-sota', the 1st Joint UMN-UW Virology Training Grant Symposium will be held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This is the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions will be presented by students, postdocs and faculty.
The 2013 IMV Symposium was held in May, 2013 and featured Vincent Racaniello as the Keynote Speaker as well as the recording of an episode of 'This Week in Virology'. Pictures from the IMV Symposium can be found on the IMV Facebook page and a videotape of the TWiV podcast can be viewed at www.twiv.tv
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.