IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Phone: (612) 626-7025
B.S., Nankai University, China, 1993
M.S., Peking University, China, 1996
Ph.D., Wayne State University, 2003
Research in his group focuses primarily on the discovery and development of novel antiviral agents. They are committed to the full spectrum of drug discovery efforts combining lead generation, SAR design, organic synthesis, viral enzyme biochemical assays, cell culture antiviral assays and pharmacology.
Chen, Y. L.; Tang, J.; Kesler, M. J.; Sham, Y. Y.; Vince, R.; Geraghty, R. J.; Wang, Z.* " The Design, Synthesis and Biological Evaluations of C-6 or C-7 Substituted 2-Hydroxyisoquinoline-1,3-diones as Inhibitors of Hepatitis C Virus ", Bioorg. Med. Chem. 2011, doi: 10.1016/j.bmc.2011.10.058.
Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "6-Benzoyl-3-hydroxypyrimidine-2,4-diones as Dual Inhibitors of HIV Reverse Transcriptase and Integrase" Bioorg. Med. Chem. Lett. 2011, 21, 2400-2402.
Tang, J.; Maddali, K.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase" J. Med. Chem. 2011, 54, 2282-2292.
Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase", ACS. Med. Chem. Lett. 2011, 2, 63-67.
Tang, J.; Maddali, K.; Pommier, Y.; Sham, Y. Y.; Wang, Z. "Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited", Bioorg. Med. Chem. Lett. 2010, 20, 3275-3279.
Wang, Z.; Tang, J.; Salomon, E. C.; Dreis, C. D.; Vince, R. "Pharmacophore and Structure-Activity-Relationship on Integrase Inhibition within a Dual Inhibitor Scaffold of HIV Reverse Transcriptase and Integrase", Bioorg. Med. Chem. 2010, 18, 4202-4211.
Wang, Z.; Vince, R. " Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine", Bioorg. Med. Chem. 2008, 16, 3587-3595.
Wang, Z.; Vince, R. "Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase", Bioorg. Med. Chem. Lett. 2008, 18, 1293-1296.
Wang, Z.; Bennett, E. M.; Wilson, D. J.; Salomon, C. and Vince, R. "Rationally Designed Dual Inhibitors of HIV Reverse Transcriptase and Integrase". J. Med. Chem. 2007, 50, 3416-3419.
'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.
The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.