IMV Executive Assistant
tel. (612) 624-1926
fax. (612) 625-1108
18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Phone: (612) 626-7025
B.S., Nankai University, China, 1993
M.S., Peking University, China, 1996
Ph.D., Wayne State University, 2003
Research in his group focuses primarily on the discovery and development of novel antiviral agents. They are committed to the full spectrum of drug discovery efforts combining lead generation, SAR design, organic synthesis, viral enzyme biochemical assays, cell culture antiviral assays and pharmacology.
Chen, Y. L.; Tang, J.; Kesler, M. J.; Sham, Y. Y.; Vince, R.; Geraghty, R. J.; Wang, Z.* " The Design, Synthesis and Biological Evaluations of C-6 or C-7 Substituted 2-Hydroxyisoquinoline-1,3-diones as Inhibitors of Hepatitis C Virus ", Bioorg. Med. Chem. 2011, doi: 10.1016/j.bmc.2011.10.058.
Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "6-Benzoyl-3-hydroxypyrimidine-2,4-diones as Dual Inhibitors of HIV Reverse Transcriptase and Integrase" Bioorg. Med. Chem. Lett. 2011, 21, 2400-2402.
Tang, J.; Maddali, K.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase" J. Med. Chem. 2011, 54, 2282-2292.
Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y.; Vince, R.; Pommier, Y.; Wang, Z. "N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase", ACS. Med. Chem. Lett. 2011, 2, 63-67.
Tang, J.; Maddali, K.; Pommier, Y.; Sham, Y. Y.; Wang, Z. "Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited", Bioorg. Med. Chem. Lett. 2010, 20, 3275-3279.
Wang, Z.; Tang, J.; Salomon, E. C.; Dreis, C. D.; Vince, R. "Pharmacophore and Structure-Activity-Relationship on Integrase Inhibition within a Dual Inhibitor Scaffold of HIV Reverse Transcriptase and Integrase", Bioorg. Med. Chem. 2010, 18, 4202-4211.
Wang, Z.; Vince, R. " Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine", Bioorg. Med. Chem. 2008, 16, 3587-3595.
Wang, Z.; Vince, R. "Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase", Bioorg. Med. Chem. Lett. 2008, 18, 1293-1296.
Wang, Z.; Bennett, E. M.; Wilson, D. J.; Salomon, C. and Vince, R. "Rationally Designed Dual Inhibitors of HIV Reverse Transcriptase and Integrase". J. Med. Chem. 2007, 50, 3416-3419.
'Wisc-e-sota', the 1st Joint UMN-UW Virology Training Grant Symposium will be held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This is the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions will be presented by students, postdocs and faculty.
The 2013 IMV Symposium was held in May, 2013 and featured Vincent Racaniello as the Keynote Speaker as well as the recording of an episode of 'This Week in Virology'. Pictures from the IMV Symposium can be found on the IMV Facebook page and a videotape of the TWiV podcast can be viewed at www.twiv.tv
Read about bacteriophage phi 29 and why it matters.
Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.
"This Week in Virology" from professor Vincent Racaniello.