Contact IMV

IMV Executive Assistant


tel. (612) 624-1926

fax. (612) 625-1108


18-242 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

General Questions:

Holly Sadler,
Staff Scientist


Phone: (612) 624-5172


BA, Biology, Macalester College

Research Interests

Role of APOBEC3 proteins in HIV evolution; HIV Vpr variation and biology

My research in the Mansky Lab primarily is focused on HIV variation. First, I am exploring the potential roles of the APOBEC3 proteins on HIV evolution, particularly in the context of sublethal mutagenesis. I am also interested in the naturally occurring genetic variation in the HIV Vpr protein as well as the role of Vpr in HIV biology.

Selected Recent Publications

  • Guenzel CA, Hérate C, Le Rouzic E, Maidou-Peindara P, Sadler HA, Rouyez MC, Mansky LM, Benichou S. 2012. Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1. J Virol. 86:2533-44.
  • Sadler, H.A., Stenglein, M.D., Harris, R.S., and L.M. Mansky. 2010. APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis. Jounral of Virology 84:7396-7404.*Article of Significant Interest Selected from This Issue by the Editors

Featured News & Events

'Wisc-e-sota', a Joint UMN-UW Virology Training Grant Symposium was first held on Friday, Sepbember 20th, 2013 at the Uniiversity of Wisconsin-La Crosse, Cartwright Center. This was the inaugural collaborative symposium of the NIH T32-supported virology training programs at the University of Wisconsin-Madison and the University of Minnesota-Twin Cities. Talks and poster sessions were presented by students, postdocs and faculty. The second UMN-UW Virology Training Grant Symposium will be held in the Fall 2014. Details to follow.

The 2014 IMV Symposium will be held on May 12, 2014 and Mark Denison (Vanderbilt) and Bert Semler (UC-Irvine) will be the Keynote Speakers. Click on the link below to register and submit abstracts.

About the IMV icon

Read about bacteriophage phi 29 and why it matters.

IMV Timeline

Explore nearly a century's worth of discovery in the field of virology at the University of Minnesota.


"This Week in Virology" from professor Vincent Racaniello.