Hu Shuxian

Assistant Professor

Infectious Diseases and International Medicine, Medical School

Email: huxxx031@umn.edu

Education

MD, Beijing University Medical School

Research Interests

Dr. Hu's major research interest is in immunologically mediated neuropathogenesis and neurodegenerative diseases of the CNS, particularly related to viral diseases of the brain. She is also interested in the effects of opioids and other psychoactive substances on neurons and glial cells.

Selected Recent Publications

• Rock RB, Hu S, Sheng WS, Peterson PK. 2006. Morphine stimulates CCL2 production by human neurons. J Neuroinflammation. 3:32.
• Hu S, Cheeran MC, Sheng WS, Ni HT, Lokensgard JR, Peterson PK. 2006. Cocaine alters proliferation, migration, and differentiation of human fetal brain-derived neural precursor cells. J Pharmacol Exp Ther. 318(3):1280-6.
• Gekker G, Hu S, Sheng WS, Rock RB, Lokensgard JR, Peterson PK. 2006. Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. Int Immunopharmacol. 6(6):1029-33.
• Shideman CR, Hu S, Peterson PK, Thayer SA. 2006. CCL5 evokes calcium signals in microglia through a kinase-, phosphoinositide-, and nucleotide-dependent mechanism. J Neurosci Res. 83(8):1471-84.
• Cheeran MC, Hu S, Sheng WS, Rashid A, Peterson PK, Lokensgard JR. 2005. Differential responses of human brain cells to West Nile virus infection. J Neurovirol. 11(6):512-24.
• Sheng WS, Hu S, Ni HT, Rowen TN, Lokensgard JR, Peterson PK. 2005. TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells. J Leukoc Biol. 78(6):1233-41.
• Rock RB, Hu S, Gekker G, Sheng WS, May B, Kapur V, Peterson PK. 2005. Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: effects of dexamethasone. J Infect Dis. 192(12):2054-8.
• Cheeran MC, Hu S, Ni HT, Sheng W, Palmquist JM, Peterson PK, Lokensgard JR. 2005. Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways. Genes Immun. 6(8):712-9.
• Gekker G, Hu S, Spivak M, Lokensgard JR, Peterson PK. 2005. Anti-HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. J Ethnopharmacol. 102(2):158-63.
• Hu S, Sheng WS, Lokensgard JR, Peterson PK. 2005. Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J Infect Dis. 191(6):886-9.
• Sheng WS, Hu S, Min X, Cabral GA, Lokensgard JR, Peterson PK. 2005. Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia. 49(2):211-9.
• Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK. 2004. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res Dev Brain Res. 152(2):159-69.
• Gekker G, Hu S, Wentland MP, Bidlack JM, Lokensgard JR, Peterson PK. 2004. Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. J Pharmacol Exp Ther. 309(2):600-6.
• Peterson PK, Gekker G, Hu S, Cabral G, Lokensgard JR. 2004. Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell cultures. J Neuroimmunol. 147(1-2):123-6.
• Cheeran MCJ, Hu S, Sheng WS, Peterson PK and Lokensgard JR. 2003. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. J. Virol. 77(8):4502-15.
• Hu S, Sheng WS, Lokensgard JR, Peterson PK. 2002. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology 42(6):829-36.
• Hu S, Ali H, Sheng WS, Ehrlich LC, Peterson PK and Chao CC. 1999. Gp-41-mediated astrocyte inducible nitric oxide synthase mRNA expression: involvement of interleukin-1b production by microglia. J. Neurosci. 19:6468-6474.