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Hiroshi Matsuo

Assistant Professor

Biochemistry, Molecular Biology and Biophysics

Email: matsu029@umn.edu
Phone: (612) 624-6421

Education

Ph.D., Osaka University, 1994

Research Interests

Protein structure

RNA structure

Protein-RNA, DNA interaction

Enzyme Kinetics

Current Projects Include:

* RNA in Viral DNA packaging
* Mechanisms of Atypical Drug Kinetics and Interactions
* Structural studies of human DEK protein

Selected Recent Publications

• Kitamura A, Jardine PJ, Anderson DL, Grimes S, Matsuo H. 2008. Analysis of intermolecular base pair formation of prohead RNA of the phage o29 DNA packaging motor using NMR spectroscopy. Nucleic Acids Res. 36(3):839-48. Epub 2007 Dec 15.
• Wise-Draper TM, Allen HV, Jones EE, Habash KB, Matsuo H, Wells SI. 2006. Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions. Mol Cell Biol. 26(20):7506-19. Epub 2006 Aug 7.
• Devany M, Matsuo H. 2005. NMR resonance assignments for the DNA-supercoiling domain of the human protein DEK. J Biomol NMR. 31(1):65. No abstract available.
• Böhm F, Kappes F, Scholten I, Richter N, Matsuo H, Knippers R, Waldmann T. 2005. The SAF-box domain of chromatin protein DEK. Nucleic Acids Res. 33(3):1101-10.
• Devany, M., Kotharu, N. P., Matsuo, H. (2004) ¿Expression and isotopic labeling of structural domains of the human protein DEK. Protein Expression and Purification. Vol 40/2 pp 244-247
• Devany M, Kotharu NP, Matsuo H. 2004. Solution NMR structure of the C-terminal domain of the human protein DEK. Protein Sci. 13(8):2252-9. Epub 2004 Jul 6.
• Matsuo, H., Moriguchi, T., Takagi, T., Kusakabe, T., Buratowski, S., Sekine, M., Kyogoku, Y. & Wagner, G. 2000. Efficient synthesis of 13C, 15N labeled RNA containing the cap structure m7GpppA. J. Am. Chem. Soc. 122, 2417-2421.
• Matsuo, H., Walters, K.J., Teruya, K., Tanaka, T., Gassner, G.T., Lippard, S.J., Kyogoku, Y. & Wagner, G. 1999. Identification by NMR spectroscopy of residues at contact surfaces in large, slowly exchanging macromolecular complexes. J. Am. Chem. Soc. 121, 9903-9904.
• Tochio H, Kojima C, Matsuo H, Yamazaki T, Kyogoku Y. 1999. Intermolecular contacts between the lambda-Cro repressor and the operator DNA characterized by nuclear magnetic resonance spectroscopy. J Biomol Struct Dyn. 16(5):989-1002.
• Chou JJ, Matsuo H, Duan H, Wagner G. 1998. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell. 94(2):171-80.
• McGuire AM, Matsuo H, Wagner G. 1998. Internal and overall motions of the translation factor eIF4E: cap binding and insertion in a CHAPS detergent micelle. J Biomol NMR. 12(1):73-88.
• Fletcher CM, McGuire AM, Gingras AC, Li H, Matsuo H, Sonenberg N, Wagner G. 1998. 4E binding proteins inhibit the translation factor eIF4E without folded structure. Biochemistry. 37(1):9-15.