Dwight L. Anderson, PhD
Professor Emeritus, Department of Microbiology and Immunology

Contact Info
Professor Emeritus, Department of Microbiology and Immunology
Department of Diagnostic and Biological Sciences
Institute for Molecular Virology
PhD, University of Minnesota, 1961
Summary
Expertise
Bacteriophage phi29 structure and assembly
Research
Research Summary/Interests
Publications
- Ding, F., C. Lu, W. Zhao, R. R. Kanagalaghatta, D. L. Anderson, P. J. Jardine, S. Grimes, and A. Ke. 2011. Structure and assembly of the essential RNA ring component of a viral DNA packaging motor. Proc. Natl. Acad. Sci. U.S.A.108:7357-7362.
- Aathavan, K., A. T. Politzer, A. Kaplan, J. R. Moffitt, Y. R. Chemla, S. Grimes, P. J. Jardine, D. L. Anderson, and C. Bustamante. 2009. Substrate Interactions and Promiscuity in a Viral DNA Packaging Motor. Nature 461:669-673.
- Xiang, Y., P. G. Leiman, L. Li, S. Grimes, D. L. Anderson, and M. G. Rossmann. 2009. Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike. Mol. Cell 34:375-386. PMC Journal - In Process.
- Cohen, D. N., Y. Y. Sham, G. D. Haugstad, Y. Xiang, M. G. Rossmann, D. L. Anderson, and D. L. Popham. 2009. Shared catalysis in virus entry and bacterial cell wall depolymerization. J. Mol. Biol. 387:607-618. PMC Journal – In Process.
- Moffitt, J. R., Y. R. Chemla, K. Aathavan, S. Grimes, P. J. Jardine, D. L Anderson, and C. Bustamante. 2009. Intersubunit coordination in a homomeric ring ATPase. Nature 457:446-450. PMC Journal - In Process.
- Zhao, W., M. C. Morais, D. L. Anderson, P. J. Jardine, and S. Grimes. 2008. Role of the CCA bulge of prohead RNA of bacteriophage ø29 in DNA packaging. J. Mol. Biol. 383:520-528. PMC Journal - In Process.
- Koti, J. S., M. C. Morais, R. Rajagopal, B. A. L. Owen, C. T. McMurray, and D. L. Anderson. 2008. DNA packaging motor assembly intermediate of bacteriophage ø29. J. Mol. Biol. 381:1114-1132. PMC Journal – In Process.
- Xiang, Y., M. C. Morais, D. C. Cohen, V. D. Bowman, D. L. Anderson, and M. G. Rossmann. 2008. Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage ø29 tail. Proc. Natl. Acad. Sci. U.S.A. 105: 9552-9557. PMCID:PMC2474476.
- Morais, M. C., J. S. Koti, V. D. Bowman, E. Reyes-Aldrete, D. L. Anderson, and M. G. Rossmann. 2008. Defining molecular and domain boundaries in the bacteriophage ø29 DNA packaging motor. Structure. 16:1267-1274. PMC Journal – In Process.
- Kitamura, A., P. J. Jardine, D. L. Anderson, S. Grimes, and H. Matsuo. 2008. Analysis of intermolecular base pair formation of prohead RNA of the phage ø29 DNA packaging motor using NMR spectroscopy. Nucleic Acids Res. 36:839-848. PMCID: PMC2241910
- Cohen, D. N., S. E. Erickson, Y. Xiang, M. G. Rossmann, and D. L. Anderson. 2008. Multifunctional roles of a bacteriophage phi 29 morphogenetic factor in assembly and infection. J. Mol. Biol. 378: 804-817. PMCID: PMC2443984.
- Tang, J., N. Olson, P. J. Jardine, S. Grimes, D. L. Anderson, and T. S. Baker. 2008. DNA poised for release in bacteriophage ø29. Structure 6:935-943. PMCID: PMC2556148.
- Comolli, L. R., A. J. Spakowitz, C. E. Siegerist, P. J. Jardine, S. Grimes, D. L. Anderson, C. Bustamante, and K. H. Downing. 2008. Three-dimensional architecture of the bacteriophage ø29 packaged genome and elucidation of its packaging process. Virology 371:267-277.
- Rickgauer, J. P., D. N. Fuller, S. Grimes, P. J. Jardine, D. L. Anderson, and D. E. Smith. 2008. Portal motor velocity and internal force resisting viral DNA packaging in bacteriophage ø29. Biophys J. 94:159-167. PMCID: PMC2134861.
- Fuller, D. N., D. M. Raymer, J. P. Rickgauer, R. M. Robertson, C. E. Catalano, D. L. Anderson, S. Grimes, and D. E. Smith. 2007. Measurements of single DNA molecule packaging dynamics in phage lambda reveal high forces, high motor processivity, and capsid transformations. J. Mol. Biol. 373:1113-1122.
- Fuller, D., J. P. Rickgauer, P. J. Jardine, S. Grimes, D. L. Anderson, and D. E. Smith. 2007. Ionic effects on viral DNA packaging and portal motor function in bacteriophage ø29. Proc. Natl. Acad. Sci. U. S. A. 104:11245-11250. PMCID: PMC2040884.
- Atz, R., S. Ma, J. Gao, D. L. Anderson, and S. Grimes. 2007. Alanine scanning and Fe-BABE probing of the bacteriophage ø29 prohead RNA-connector interaction. J. Mol. Biol. 369:239-248. PMCID: PMC1976407
- Hugel, T., J. Michaelis, C. L. Hetherington, P. J. Jardine, S. Grimes, J. M. Walter, W. Falk, D. L. Anderson, and C. Bustamante. 2007. Experimental test of connector rotation during DNA packaging into bacteriophage ø29 capsids. PLoS Biol. 5:e59. PMCID: PMC1800307.
- Xiang, Y., M. C. Morais, A. J. Battisti, S. Grimes, P. J. Jardine, D. L. Anderson, and M. G. Rossmann. 2006. Structural changes of bacteriophage ø29 upon DNA packaging and release. EMBO J. 25:5229-5239. PMCID: PMC1630414.
- Jardine, P. J. and D. Anderson. 2006. DNA packaging in double-stranded DNA bacteriophages. In The Bacteriophages, R. Calendar, ed., Oxford Press, Chapter 6, 49-65.
- Choi, K. H., M. C. Morais, D. L. Anderson, and M. G. Rossmann. 2006. Determinants of bacteriophage ø29 head morphology. Structure 14:1723-1727.
- Morais, M. C., K. H. Choi, J. S. Koti, P. R. Chipman, D. L. Anderson, and M. G. Rossmann. 2005. Conservation of the capsid structure in tailed dsDNA bacteriophages: the pseudoatomic structure of ø29. Mol. Cell 18:149-159.
- Chemla, Y. R., K. Aathavan, J. Michaelis, S. Grimes, P. J. Jardine, D. L. Anderson, and C. Bustamante. 2005. Mechanism of force generation of a viral DNA packaging motor. Cell 122: 683-692.
- Anderson, D. and S. Grimes. 2005. The ø29 DNA packaging motor: seeking the mechanism. In Viral Genome Packaging. C. Catalano, ed., Landes Bioscience, Chapter 7.