Frank S. Rhame, MD

Professor of Medicine (Joint Appointment), Division of Infectious Diseases and International Medicine

Frank S. Rhame

Contact Info

Fax 612-863-5467

Office Address:
AMC - The Doctors, Uptown
Suite 201
1221 W Lake
Minneapolis, MN 55408

Mailing Address:
AMC - The Doctors Uptown
Ste 201
1221 W Lake St
Minneapolis, MN 55408

Professor of Medicine (Joint Appointment), Division of Infectious Diseases and International Medicine

Division of Epidemiology and Community Health (EpiCH)

Institute for Molecular Virology

School of Public Health

Clinical Management of HIV Infection

Medical School, Columbia University, New York City, NY

BS, California Institute of Technology



Clinical management of HIV infection


Research Summary/Interests

HIV Therapy


  • Kakuda TN, Page LM, Anderson PL, Henry K, Schacker TW, Rhame FS, Acosta EP,Brundage RC, Fletcher CV. Pharmacological basis for concenration-controlled therapy with zidovudine, lamivudine,and indinavir. Antimicrob Agents and Chemother 2001;45:236-42.
  • Chaloner K, Rhame FS. Quantifying and coumenting prior beliefs in clinical trials. Statistics in Medicine 2001;20:581-600.
  • Rhame, FS. Uncertain generalizability of switch studies (letter). CID 2003;36:1089
  • Rhame FS. Methicillin-resistant Staphylococcus aureus. [letter] Am J Med 1995;98:599-600.
  • Fletcher CV. Collier AC, Rhame FS, Bennett D, Para MF, Beatty CC, et al. Foscarnet for suppression of HIV replication. Antimicrob Agents Chemother 1994;38:604-7.
  • Little JW, Melnick SL, Rhame FS, Balfour HH Jr, Decher L, Rhodus NL,Merry JW, WalkerPO, Miller CE, Volberding P.
    Prevalence of oral lesions in symptomatic and asymptomatic HIV patients. Gen Dentistry 1994;42:446-50.
  • Neaton JD, Wentworth DN, Rhame FS, Hogan C, Abrams DI, Deyton L. Considerations in choice of a clinical endpoint for AIDS clinical trials. Statistics in Medicine 1994;13:2107-25.
  • Noormohamed SE, Henry WK, Rhame FS, Balfour HH Jr, Fletcher CV. Strategies for control of zidovudine concentrations in serum. Antimicrob Agents Chemother 1995;39:2792-7
  • Rhame FS. FDA labeling requirements for disinfection of endoscopes: a counterpoint.[letter] Infect Control Hosp Epidemiol 1995;16:497.
  • Fletcher CV, Henry WK, Noormohamed SE, Rhame FS, Balfour HH Jr.The effect of cimetidine and ranitidine administration with zidovudine.Pharmacotherapy 1995;15:701-8.
  • Wells CL, Juni BA, Cameron SB, Mason KR, Dunn DL, Ferrieri P, Rhame FS. Stool carriage, clinical isolation, and mortality during an outbreak of vancomycin-resistant enterococci in hospitalized medical and/or surgical patients. Clin Infect Dis 1995;21:45-50.
  • Carlin BP, Chaloner KM, Louis TA, Rhame FS. Elicitation, monitoring, and analysis for and AIDS clinical trial. In: Case Studies in Bayesian Statistics (Gatsonis C, Hodges JS, Kass RE, Singpurinalland, eds.), Springer 1995.
  • Gunderson M, Mayo D, Rhame FS. Routine HIV testing of hospital patients and pregnant women: informedconsent in the real world. Kennedy Institute of Ethics Journal 1996;6:161-96.
  • Mildvan D, Bassiakos Y, Zucker ML, Hyslop N Jr, Krown SE, Sacks HS, Zachary J, Paredes J, Fessel WJ, Rhame F, et al.
    Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: ACTG 068. Antiviral Therapy 1996;1:77-88.
  • Saravolatz L, Neaton JD, Sacks L, Deyton L, Rhame F, Sherer R. CD4+ T lymphocyte counts and patterns of mortality among patients infected with human immunodeficiency virus who were enrolled in community programs for clinical research on AIDS. Clin Infect Dis 1996;22:513-20.
  • Michalova K, Moyes AL, Cameron S, Juni BA, Obritsch WF, Dvorak JA, Rhame FS. Povidone-iodine (Betadine) in the treatment of experimental Pseudomonas aeruginosa infectious keratitis. Cornea 1996;15:533-6.
  • Fletcher CV, Goodroad BK, Cummins LM, Henry K, Balfour HH Jr, Rhame FS. Pharmacokinetics of hyperimmune anti-human immunodeficiency virus I immunoglobulin in persons with AIDS. Antimicrob Agents Chemother 1997;41:1571-4.
  • Green LA, Rhame FS, Price RW, Perlman D, Capps L, Sampson J, Deyton L, Schnittman S, et al. Experience with a cross-study endpoint review committee for AIDS clinical trials. AIDS 1998;12:1983-90
  • Dobs AS, Cofrancesco J, Noltyen WE, Danoff A, Anderson R, Hamilton CD, Feinberg J,
    Seekins D, Yangco B, Rhame F.
    The use of transscrotal testosterone delivery system in the treatment of patients with weight
    loss related to human immunodeficiency virus infection.
    Am J Med 1999;107:126-32.
  • Rhame FS. Implications of market baskets, a pharmaceutical marketing practice [letter]. JAMA 1999;282:1134.