Maxim C. Cheeran, DVM, PhD

Associate Professor, Department of Veterinary Population Medicine (VPM)

Maxim C. Cheeran

Contact Info

Office Phone 612-626-9930

Office Address:
225 Veterinary Medical Center
1365 Gortner Avenue
St. Paul, MN 55108

Mailing Address:
Veterinary Population Medicine
Room 225 VetMedCtrN
6190A
1365 Gortner Ave
St Paul, MN 55108

PhD, University of Minnesota, 2000

MVSc, Indian Veterinary Research Institute, 1995

BVSc & AH College of Veterinary and Animal Sciences, 1992

Summary

Maxim C-J. Cheeran received his Veterinary training (DVM) in India and his PhD from the University of Minnesota. His primary research focuses on studying neuroimmune responses against cytomegalovirus brain infection. His studies utilize a murine model of CMV brain infection to investigate the role of peripheral immune cells in controlling virus dissemination in the CNS . His other research interests include understanding the cellular mechanisms by which viruses and immune mediators alter neurogenesis within the CNS. He is actively involved in developing both in vitro and in vivo models to study modulation of neural stem cell function during viral infections. The ultimate goal of these studies is to develop novel therapies for viral encephalitis.

Research

Research Summary/Interests

Neuroimmune response to brain infections Neuroimmune responses are both essential for protection and induce brain damage. Our lab is interested in understanding the mechanisms that mediate these effects in an effort to develop interventions that shift the balance from damage to repair, particularly addressing chronic brain disease ensuing infections. Neural Stem cell response to neuroinflammation Neural stem cells (NSCs) are undifferentiated cells in the brain that is believed to be a cellular source for new neuron formation. Our lab investigates the mechanisms by which NSCs interact with the inflammatory milieu generated during viral encephalitis. Pathogenesis of zoonotic infections We study porcine T cell responses to swine influenza viruses to understand its impact on viral fitness and pathogenesis.

Publications

  • Cheeran MC-J, Hu S, Sheng WS, Rashid A, Peterson PK, and Lokensgard JR. Glial cell responses to West Nile virus infection. J Neurovirol. 2005; In press.
  • Cheeran MC-J, Gekker G, Hu S, Palmquist JM, Lokensgard JR. T cell mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-g. J Neurovirol. 2005; 11:274-280
  • Cheeran MC-J, Gekker G, Hu S, Lokensgard JR. Intracerebral infection with murine cytomegalovirus is restricted by adoptive transfer of splenocytes. J Neurovirol. 2004; 10(3) 152-162
  • Cheeran MC-J, Hu S, Sheng W, Peterson PK, Lokensgard JR. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. J Virol. 2003; 77:4502-4515
  • Cheeran MC-J, Hu S, Yager SL, Gekker G, Peterson PK, Lokensgard JR. Cytomegalovirus induces cytokine and chemokine production differentially in human glial cells: antiviral implications. J Neurovirol. 2001; 7:135-147.
  • Cheeran MC-J, Hu S, Gekker G, Lokensgard JR. Decreased cytomegalovirus expression following proinflammatory cytokine treatment of primary human astrocytes. J Immunol. 2000; 164: 926-933.

Teaching

Teaching Areas

Veterinary Virology; PharmacoNeuroImmunology