Perry B. Hackett, PhD

Professor, Department of Genetics, Cell Biology and Development

Perry B. Hackett

Contact Info

hacke004@umn.edu

Office Phone 612-624-6736

Fax 612-626-6140

Lab Phone 612-624-4206

Office Address:
5-108 MolCellBio
420 Washington Ave SE
Minneapolis, MN 55455

Mailing Address:
Genetics, Cell Biology/Dev
Room 6-160 JacH
1217A
321 Church St SE
Minneapolis, MN 55455

Lab Address:
5-206 MCB

PhD, University of Colorado, 1974

Research

Research Summary/Interests

The Hackett lab's main area of interest is using transposons as vectors for gene therapy as well as tagging and mapping genes in vertebrate chromosomes. For this, we use the Sleeping Beauty Transposon System, a system we created from extinct transposons that had been asleep for more than 10 million years. The lab works very closely with other labs in the Center for Genome Engineering including the McIvor, Largaespada, Somia and Voytas labs.

Publications

Hackett, P.B., Fahrenkrug, S.C., Carlson, D.F. (2015). The promises and challenges of precision gene editing in animals of agricultural importance. IN Eaglesham, A. and Hardy, R.W.F, eds. New DNA-Editing Approaches: Methods, Applications and Policy for Agriculture. NABC Report 26, pp. 39-.

Hackett, P., Carroll, D. (2015). Regulatory hurdles for agriculture GMOs. Science 347: 1324. Watson, A.L., Carlson, D.F., Largaespada, D.A., Hackett, P.B., and Fahrenkrug, S.C. (2016). Engineered swine models of cancer. In Frontiers in Genetics, Cancer Genetics. 7: 78

Dhande, Y.K., Wagh, B.S., Hall, B.C., Sprouse, D.S., Hackett, P.B., and Reineke, T.M. (2016) N-acetylgalactosamine block-co-polycations form stable complexes with plasmids and promote liver-targeted delivery. Biomacromolecules 17: 830-840

Tolstyka, Z.P., Phillips, H., Cortez, M., Wu, Y., Ingle, N., Bell, J.B., Hackett, P.B., and Reineke, T.M. (2016) Trehalose-based block copolymers for in vitro and in vivo non-viral DNA delivery. Biomaterials ACS Biomat. Sci. Eng. 2: 43-55.

Kebriae, P., Singh H., Huls, M.H., Figliola, M.J., Bassett, R., Olivares, S., Ang, S., Dawson, M.J., Kumaresan, P.R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M.A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R.N., MoyesJ.S., Rondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E.J., Kantarjian, H., Keating, M.,Wierda, M., Do, K.A., Largaespada, D.A., Lee, D.A., Hackett, P.B., Champlin, R.E., and Cooper, L.J.N. (2016) Phase I trials using Sleeping Beauty to generate CD19-specific T cells. J. Clin. Invest. 126: 3363-3376